In an update to an ongoing multi-center prospective study of 740 consecutively enrolled total knee replacement patients, those who received an iTotal® CR implant were significantly faster than patients with an off-the-shelf implant at completing three functional tests of daily living: walking, getting in and out of a chair and walking up and down stairs. Study investigators used a validated functional test known as the Aggregated Locomotor Function (ALF) test, in which blinded operators assessed patients’ ability to perform these activities of daily living. Additionally, an analysis using the 2011 New Knee Society Score (KSS) found no statistically significant differences. This study was presented at the 2016 ICJR Pan Pacific Orthopaedic Congress. Conformis provided financial support for this study.